ParkinsonCanadaV1, Main, Exploration, bibRecord, 000455

A brain network model explaining tremor in Parkinson's disease.

Identifieur interne : 000455 ( Main/Exploration ); précédent : 000454; suivant : 000456

A brain network model explaining tremor in Parkinson's disease.

Auteurs : Christian Duval [Canada] ; Jean-Francois Daneault [États-Unis] ; William D. Hutchison [Canada] ; Abbas F. Sadikot [Canada]

Source :

Neurobiology of disease [ 1095-953X ] ; 2016.

RBID : pubmed:26459110

English descriptors

KwdEn :
- Action Potentials, Animals, Brain (physiopathology), Humans, Models, Neurological, Neural Pathways (physiopathology), Neurons (physiology), Parkinson Disease (physiopathology).
MESH :
- physiology : Neurons.
- physiopathology : Brain, Neural Pathways, Parkinson Disease.
- Action Potentials, Animals, Humans, Models, Neurological.

Abstract

This paper presents a novel model of tremor in Parkinson's disease (PD) based on extensive literature review as well as novel results stemming from functional stereotactic neurosurgery for the alleviation of tremor in PD. Specifically, evidence that suggests the basal ganglia induces PD tremor via excessive inhibitory output to the thalamus and altered firing patterns which in turn generate rhythmic bursting activity of thalamic cells is presented. Then, evidence that the thalamus generates PD tremor by facilitating the generation and consolidation of rhythmic bursting activity of neurons within its nuclei is also offered. Finally, evidence that the cerebellum may modulate characteristics of PD tremor by treating it as if it was a voluntary motor behavior is presented. Accordingly, the current paper proposes that PD tremor is induced by abnormal basal ganglia activity; it is generated by the thalamus, and modulated or reinforced by the cerebellum.

DOI: 10.1016/j.nbd.2015.10.009
PubMed: 26459110

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A brain network model explaining tremor in Parkinson's disease.</title>
<author><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name>
<affiliation wicri:level="4"><nlm:affiliation>Département des sciences de l'activité physique, Université du Québec à Montréal, Montréal, Canada; Laboratoire d'évaluation des Troubles du Mouvement, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada. Electronic address: duval.christian@uqam.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Département des sciences de l'activité physique, Université du Québec à Montréal, Montréal, Canada; Laboratoire d'évaluation des Troubles du Mouvement, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université du Québec à Montréal</orgName>
</affiliation>
</author>
<author><name sortKey="Daneault, Jean Francois" sort="Daneault, Jean Francois" uniqKey="Daneault J" first="Jean-Francois" last="Daneault">Jean-Francois Daneault</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'évaluation des Troubles du Mouvement, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; Motion Analysis Laboratory, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, US.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratoire d'évaluation des Troubles du Mouvement, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; Motion Analysis Laboratory, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston</wicri:regionArea>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Surgery and Physiology, University of Toronto, Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital, Toronto, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Surgery and Physiology, University of Toronto, Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sadikot, Abbas F" sort="Sadikot, Abbas F" uniqKey="Sadikot A" first="Abbas F" last="Sadikot">Abbas F. Sadikot</name>
<affiliation wicri:level="4"><nlm:affiliation>Cone Laboratory, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Cone Laboratory, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26459110</idno>
<idno type="pmid">26459110</idno>
<idno type="doi">10.1016/j.nbd.2015.10.009</idno>
<idno type="wicri:Area/PubMed/Corpus">000338</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000338</idno>
<idno type="wicri:Area/PubMed/Curation">000338</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000338</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000338</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000338</idno>
<idno type="wicri:Area/Ncbi/Merge">001D43</idno>
<idno type="wicri:Area/Ncbi/Curation">001D43</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001D43</idno>
<idno type="wicri:Area/Main/Merge">000456</idno>
<idno type="wicri:Area/Main/Curation">000455</idno>
<idno type="wicri:Area/Main/Exploration">000455</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A brain network model explaining tremor in Parkinson's disease.</title>
<author><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name>
<affiliation wicri:level="4"><nlm:affiliation>Département des sciences de l'activité physique, Université du Québec à Montréal, Montréal, Canada; Laboratoire d'évaluation des Troubles du Mouvement, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada. Electronic address: duval.christian@uqam.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Département des sciences de l'activité physique, Université du Québec à Montréal, Montréal, Canada; Laboratoire d'évaluation des Troubles du Mouvement, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université du Québec à Montréal</orgName>
</affiliation>
</author>
<author><name sortKey="Daneault, Jean Francois" sort="Daneault, Jean Francois" uniqKey="Daneault J" first="Jean-Francois" last="Daneault">Jean-Francois Daneault</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'évaluation des Troubles du Mouvement, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; Motion Analysis Laboratory, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, US.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratoire d'évaluation des Troubles du Mouvement, Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; Motion Analysis Laboratory, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston</wicri:regionArea>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Surgery and Physiology, University of Toronto, Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital, Toronto, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Surgery and Physiology, University of Toronto, Toronto, Canada; Division of Neurosurgery, Toronto Western Hospital, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sadikot, Abbas F" sort="Sadikot, Abbas F" uniqKey="Sadikot A" first="Abbas F" last="Sadikot">Abbas F. Sadikot</name>
<affiliation wicri:level="4"><nlm:affiliation>Cone Laboratory, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Cone Laboratory, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Neurobiology of disease</title>
<idno type="eISSN">1095-953X</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials</term>
<term>Animals</term>
<term>Brain (physiopathology)</term>
<term>Humans</term>
<term>Models, Neurological</term>
<term>Neural Pathways (physiopathology)</term>
<term>Neurons (physiology)</term>
<term>Parkinson Disease (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term>
<term>Neural Pathways</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Action Potentials</term>
<term>Animals</term>
<term>Humans</term>
<term>Models, Neurological</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This paper presents a novel model of tremor in Parkinson's disease (PD) based on extensive literature review as well as novel results stemming from functional stereotactic neurosurgery for the alleviation of tremor in PD. Specifically, evidence that suggests the basal ganglia induces PD tremor via excessive inhibitory output to the thalamus and altered firing patterns which in turn generate rhythmic bursting activity of thalamic cells is presented. Then, evidence that the thalamus generates PD tremor by facilitating the generation and consolidation of rhythmic bursting activity of neurons within its nuclei is also offered. Finally, evidence that the cerebellum may modulate characteristics of PD tremor by treating it as if it was a voluntary motor behavior is presented. Accordingly, the current paper proposes that PD tremor is induced by abnormal basal ganglia activity; it is generated by the thalamus, and modulated or reinforced by the cerebellum.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Ontario</li>
<li>Québec</li>
</region>
<settlement><li>Boston</li>
<li>Montréal</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université de Toronto</li>
<li>Université du Québec à Montréal</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Québec"><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name>
</region>
<name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
<name sortKey="Sadikot, Abbas F" sort="Sadikot, Abbas F" uniqKey="Sadikot A" first="Abbas F" last="Sadikot">Abbas F. Sadikot</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Daneault, Jean Francois" sort="Daneault, Jean Francois" uniqKey="Daneault J" first="Jean-Francois" last="Daneault">Jean-Francois Daneault</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000455 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000455 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:26459110
   |texte=   A brain network model explaining tremor in Parkinson's disease.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26459110" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

A brain network model explaining tremor in Parkinson's disease.

A brain network model explaining tremor in Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.